新科学想法 › 学术文库 › 学术文献 › 浏览文献

Safety of sputum induction with isotonic saline in adults with acute severe asthma

阿平添加于 2009-6-26 03:18 | 3300 次阅读 | 0 个评论

作者
Wark PA, Simpson JL, Hensley MJ, Gibson PG
摘要
BACKGROUND: Sputum induction is a safe and effective technique to study airway inflammation in stable asthma. However, it has the potential to induce bronchospasm and the safety and efficacy of the technique in acute asthma has not been determined. OBJECTIVE: The objective of this study was to evaluate the safety and efficacy of a protocol to induce sputum using isotonic saline in adults with acute exacerbations of asthma. METHODS: Adults (n = 47) presenting to the emergency room with acute asthma and an FEV1 > 1.0 L underwent supervised sputum induction with 0.9% saline delivered by an ultrasonic nebuliser. Induction was ceased if there was a fall of 20% or greater from baseline FEV1. RESULTS: Subjects had moderate to severe exacerbations of acute asthma. An adequate sputum sample was obtained in 87% of subjects. Four subjects ceased induction because of symptom distress. There was a fall > or = 20% in 28% of subjects. Bronchoconstriction was successfully reversed by salbutamol in all subjects. Predictors of significant bronchoconstriction were older age, use of ingested corticosteroids, and a requirement for high-dose nebulized salbutamol for the exacerbation. Maintenance long-acting beta2-agonist therapy protected against bronchoconstriction during sputum induction. CONCLUSIONS: Sputum induction in acute asthma using isotonic saline is highly efficacious in obtaining an adequate sputum sample. There is the potential for significant bronchoconstriction to occur but this can be managed safely with minimal discomfort to subjects.
详细资料
- 关键词: Acute Disease; Adolescent; Adrenergic beta-Agonists/administration & dosage; Adult; Age Factors; Aged; Aged, 80 and over; Albuterol/administration & dosage; Anti-Inflammatory Agents/therapeutic use; Asthma/*drug therapy; Australia; Bronchoconstriction/drug effects; Bronchodilator Agents/*therapeutic use; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume/drug effects; Humans; Isotonic Solutions/*pharmacology; Male; Middle Aged; Predictive Value of Tests; Prednisone/therap
- 文献种类: Journal Article
- 期刊名称: Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology
- 期刊缩写: Clin Exp Allergy
- 期卷页: 2001年第31卷第11期 1745-1753页
- 地址: Airways Research Centre, John Hunter Hospital, and Faculty of Medicine, University of Newcastle, Newcastle, New South Wales, Australia
- ISBN: 0954-7894
- 备注:PMID:11696051
学科领域生物医药 » 生物学
标签

哮喘等张生理盐水
相关链接 URL
附件
Safety of sputum induction with isotonic saline in adults with acute severe asthma