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TGFβ signalling: a complex web in cancer progression

热1 xbinbzy 添加于 2010-5-26 20:11 | 2512 次阅读 | 2 个评论

作者
Ikushima H, Miyazono K
摘要
The distortion of growth factor signalling is the most important prerequisite in tumour progression. Transforming growth factor-β (TGFβ) signalling regulates tumour progression by a tumour cell-autonomous mechanism or through tumour–stroma interaction, and has either a tumour-suppressing or tumour-promoting function depending on cellular context. Such inherent complexity of TGFβ signalling results in arduous, but promising, assignments for developing therapeutic strategies against malignant tumours. As numerous cellular context-dependent factors tightly maintain the balance of TGFβ signalling and contribute to the regulation of TGFβ-induced cell responses, in this Review we discuss how they maintain the balance of TGFβ signalling and how their collapse leads to tumour progression.
详细资料
- 文献种类:期刊
- 期刊名称: Nature Reviews Cancer
- 期刊缩写: Nat Rev Cancer
- 期卷页: 2010年第10卷第6期 415-424页
- ISBN: 1474-175X
相关链接 DOI URL