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Balancing cell adhesion and Wnt signaling, the key role of β-catenin

热1 groupmaster 添加于 2010-11-9 09:49 | 3129 次阅读 | 1 个评论

作者
BREMBECK F, ROSARIO M, BIRCHMEIER W
摘要
Controlled regulation of cell proliferation and differentiation is essential for embryonic development and requires the coordinated regulation of cell-cell adhesion and gene transcription. The armadillo repeat protein beta-catenin is an important integrator of both processes. Beta-catenin acts in the Wnt signaling pathway, activating the transcription of crucial target genes responsible for cellular proliferation and differentiation. Beta-catenin also controls E-cadherin-mediated cell adhesion at the plasma membrane and mediates the interplay of adherens junction molecules with the actin cytoskeleton. Both functions of beta-catenin are de-regulated in human malignancies, thereby leading both to the loss of cell-cell adhesion and to the increased transcription of Wnt target genes.
详细资料
- 文献种类:期刊
- 期刊名称: Current Opinion in Genetics & Development
- 期刊缩写: Current Opinion in Genetics & Development
- 期卷页: 2006年第16卷第1期 51-59页
- ISBN: 0959437X
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骨科学
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