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Mediodorsal nucleus of the thalamus is critical for the expression of memory of methamphetamine-produced conditioned place preference in rats

shenww 添加于 2011-1-25 14:06 | 2406 次阅读 | 0 个评论

作者
Kuo C-S, Chai S-C, Chen H-H
摘要
Methamphetamine (MA) is a powerful and highly addictive psychostimulant. However, the neural substrate mediating MA-induced conditioned effects, an essential part of addiction, remains unclear. The present study investigated the involvement of the anterior cingulate cortex (ACC), the lateral nucleus of amygdala (LNA), and the mediodorsal nucleus of the thalamus (MD) in MA-conditioned place preference (CPP). Rats underwent bilateral radio-frequency lesions of the ACC, LNA, or MD followed by MA CPP training. Lesions of the MD, but not the ACC or LNA, disrupted MA CPP learning. To clarify the role of the MD on the different stages of the MA CPP memory process, bilateral microinfusions of lidocaine into the MD were performed 5 min prior to each conditioning trial, immediately after the conditioning trial, or 5 min before the testing phase. Pretesting, but not pre-or post-conditioning, infusions of lidocaine into the MD impaired MA CPP. Furthermore, a clear preference for the previously conditioned MA paired cues was expressed when the rats were tested again 24 h after infusions of lidocaine. These results are interpreted as indicating that the MD is specifically involved in the memory retrieval process of MA associated memory which suggests the MD could have an important role in relapse in individuals suffering from MA addiction. Keywords: methamphetamine; mediodorsal nucleus of thalamus; medial prefrontal cortex; the lateral nucleus of amygdala; conditioned place preference Corresponding author: Hwei-Hsien Chen, Institute of Pharmacology and Toxicology, Tzu Chi University, 701, Section 3, Chung-Yang Road, Hualien, 970, TAIWAN, Tel:886-3-856-5301 ext.2450, Fax:886-3-856-1465
详细资料
- 文献种类:期刊
- 期刊名称: Neuroscience
- 期刊缩写: Neuroscience
- 期卷页: 2011年
- ISBN: 0306-4522
标签

meth CPP ACC memory retrieval lateral nucleus of amygdala mediodorsal nucleus of the thalamus
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摘要

丘脑内侧背核参与到meth相关记忆的retrieval process