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Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats

热1 sunxjk 添加于 2011-2-5 21:03 | 3259 次阅读 | 0 个评论

作者
Sun Q, Kang Z, Cai J, Liu W, Liu Y, Zhang JH, Denoble PJ, Tao H, Sun X
摘要
Protective effect of hydrogen (H(2)) gas on cardiac ischemia-reperfusion (I/R) injury has been demonstrated previously. This study was designed to test the hypothesis that hydrogen-rich saline (saline saturated with molecular hydrogen), which is easy to use, induces cardioprotection against ischemia (30 min) and reperfusion (24 h) injury in rats. Adult male Sprague-Dawley rats underwent 30-min occlusion of the left anterior descending (LAD) coronary artery and 24-h reperfusion. Intraperitoneal injection of hydrogen-rich saline before reperfusion significantly decreased plasma and myocardium malondialdehyde (MDA) concentration, decreased cardiac cell apoptosis, and myocardial 8-hydroxydeoxyguanosine (8-OHdG) in area at risk zones (AAR), suppressed the activity of caspase-3, and reduced infarct size. The heart function parameters including left ventricular systolic pressure (LVSP), left ventricular diastolic pressure (LVDP), +(dP/dt)(max) and -(dP/dt)(max) were also significantly improved 24 h after reperfusion. It is concluded that hydrogen-rich saline is a novel, simple, safe, and effective method to attenuate myocardial I/R injury.
详细资料
- 文献种类:期刊
- 期刊名称: Experimental Biology and Medicine (Maywood, N.J.)
- 期刊缩写: Exp Biol Med (Maywood)
- 期卷页: 2009年第234卷第10期 1212-1219页
- 地址: Department of Diving Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, P. R. China. sunxjk@hotmail.com
- ISBN: 1535-3699
- 备注:PMID:19596825
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Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats
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