新科学想法 › 文献管理 › 浏览文献

MicroRNA binding-site polymorphisms as potential biomarkers of cancer risk

icecream 添加于 2013-1-12 19:37 | 1910 次阅读 | 0 个评论

作者
Blitzblau RC, Weidhaas JB
摘要
Identification of people or populations at risk for developing cancer is a key to improved screening programs and earlier detection, with the hope of a commensurate reduction in cancer mortalities. Genetic alterations that change gene expression levels have long been investigated for association with development of cancer. Misregulation of genes through altered interactions is another potential mechanism of oncogenesis. Gene regulation by microRNAs (miRNAs) is a relatively new area of study, and a growing body of evidence suggests that alterations in this process may be associated with increased cancer risk. This can occur through alterations in miRNA levels, interactions with targets, or perhaps more complicated combinations of the two. Here we review the current data for association between single nucleotide polymorphisms (SNPs) in miRNA binding sites and specific cancers. This growing body of literature suggests that these SNPs have a potential role as biomarkers for cancer risk.
详细资料
- 关键词: Binding Sites/*genetics; Genetic Predisposition to Disease; Humans; MicroRNAs/*genetics/*metabolism; Neoplasms/*genetics; *Polymorphism, Single Nucleotide; Tumor Markers, Biological/*genetics
- 文献种类:期刊
- 期刊名称: Molecular Diagnosis & Therapy
- 期刊缩写: Mol Diagn Ther
- 期卷页: 2010年第14卷第6期 335-342页
- 地址: Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina, USA
- ISBN: 1177-1062
相关链接 DOI URL