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Role of oxidative stress and nitric oxide in atherothrombosis

jbzy513 添加于 2010-1-12 22:01 | 1524 次阅读 | 0 个评论

作者
Lubos E, Handy DE, Loscalzo J
摘要
During the last decade basic and clinical research has highlighted the central role of reactive oxygen species (ROS) in cardiovascular disease. Enhanced production or attenuated degradation of ROS leads to oxidative stress, a process that affects endothelial and vascular function, and contributes to vascular disease. Nitric oxide (NO), a product of the normal endothelium, is a principal determinant of normal endothelial and vascular function. In states of inflammation, NO production by the vasculature increases considerably and, in conjunction with other ROS, contributes to oxidative stress. This review examines the role of oxidative stress and NO in mechanisms of endothelial and vascular dysfunction with an emphasis on atherothrombosis.
详细资料
- 关键词: Aerobiosis; Animals; Atherosclerosis/*physiopathology; Endothelium, Vascular/physiology/physiopathology; Humans; Nitric Oxide/*physiology; *Oxidative Stress; Peroxynitrous Acid/metabolism; Thrombosis/*physiopathology
- 文献种类:期刊
- 期刊名称: Frontiers in Bioscience : a Journal and Virtual Library
- 期刊缩写: Front Biosci
- 期卷页: 2008年第13卷 5323-5344页
- 地址: Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts 02115, USA
- ISBN: 1093-4715
- 备注:PMID:18508590
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