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Tyrosine nitration: localisation, quantification, consequences for protein function and signal transduction

jbzy513 添加于 2010-1-13 11:15 | 1668 次阅读 | 0 个评论

作者
Greenacre SA, Ischiropoulos H
摘要
The nitration of free tyrosine or protein tyrosine residues generates 3-nitrotyrosine the detection of which has been utilised as a footprint for the in vivo formation of peroxynitrite and other reactive nitrogen species. The detection of 3-nitrotyrosine by analytical and immunological techniques has established that tyrosine nitration occurs under physiological conditions and levels increase in most disease states. This review provides an updated, comprehensive and detailed summary of the tissue, cellular and specific protein localisation of 3-nitrotyrosine and its quantification. The potential consequences of nitration to protein function and the pathogenesis of disease are also examined together with the possible effects of protein nitration on signal transduction pathways and on the metabolism of proteins.
详细资料
- 关键词: Animals; Disease; Humans; Nitrates/*metabolism; Proteins/metabolism/*physiology; *Signal Transduction; Tyrosine/*analogs & derivatives/analysis/*metabolism/physiology
- 文献种类:期刊
- 期刊名称: Free Radical Research
- 期刊缩写: Free Radic Res
- 期卷页: 2001年第34卷第6期 541-581页
- 地址: Centre for Cardiovascular Biology and Medicine and Wolfson Centre for Age-related Disease, King's College London, Guy's Campus, London, SE1 1UL, UK
- ISBN: 1071-5762
- 备注:PMID:11697033
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6b
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