新科学想法 › 文献管理 › 浏览文献

ATP-dependent chromatin remodeling enzymes and their various roles in cell cycle control

鹿特丹添加于 2009-7-15 06:48 | 1985 次阅读 | 0 个评论

作者
Morettini S, Podhraski V, Lusser A
摘要
The modification of chromatin structure by various mechanisms has emerged as a key regulatory component of nuclear programs. Cell cycle progression and exit are affected by the integrity of chromatin architecture as well as by regulatory cues that chromatin structure imposes on the expression of cell cycle genes. ATP-dependent chromatin remodeling factors use the energy derived from ATP-hydrolysis to modulate histone-DNA contacts. These molecular machines play important roles in all aspects of chromosome biology and are thus intimately linked to cell cycle control. Regulation of complex activity by various signaling pathways has been a rising theme in recent years. Moreover, some chromatin remodeling factors have been characterized as potent tumor suppressor proteins. Thus, to understand the functions and activities of ATP-utilizing chromatin remodeling factors is an important goal towards their use as potential targets in cancer therapy.
详细资料
- 关键词: Adenosine Triphosphate/*metabolism; Animals; Cell Cycle/*physiology; Chromatin/*physiology/ultrastructure; DNA Repair; Gene Expression Regulation; Homeostasis/*physiology; Humans; Mitosis/physiology
- 文献种类:期刊
- 期刊名称: Frontiers in Bioscience : a Journal and Virtual Library
- 期刊缩写: Front Biosci
- 期卷页: 2008年第13卷 5522-5532页
- 地址: Division of Molecular Biology, Biocenter, Innsbruck Medical University, Fritz-Pregl Strasse 3, A-6020 Innsbruck, Austria
- ISBN: 1093-4715
- 备注:PMID:18508602
标签

ATP 细胞周期
相关链接 URL
鹿特丹的文献笔记订阅

全文下载不到，求助呀