在肾脏国际杂志上，最近有一篇评论文章，题目是“氢气：另一个具有治疗潜力的气体”。该文章是对同一杂志美国匹大移植中心
关于含氢水治疗移植后肾病论文的评论。这是目前美国对氢气研究最前沿的小组，负责人是日裔教授Nakao，他们已经先后发表了氢气对小肠、心脏和肾脏移植方面的文章，可以说是移植与氢气方面具有特点。这个评论文章没有看到全文，从摘要看没有什么值得看的内容。本文的日文全文
[PDF] 水素―新しい治療的医学ガスhra-japan.org [PDF][size=-1]
JF George, A Agarwal - hra-japan.org
Page 1. 編集者の論評 （掲載論文の解説） 水素―新しい治療的医学ガス James F.
George1,3 and Anupam Agarwal2,3 1Department of Surgery, Division of Cardiothoracic
Surgery and the 2Department of Medicine, Division of Nephrology
...
Hydrogen: another gas with therapeutic potential
James F George & Anupam Agarwal
Abstract
Cardinal and colleagues describe the use of molecular hydrogen, the most abundant molecule in the universe, as a treatment for chronic allograft nephropathy (CAN) in a rat model of kidney transplantation. They demonstrate that the addition of hydrogen to the drinking water results in a decrease in the severity of CAN and increased graft survival, and they provide evidence that the mechanism of action could be due to a reduction in reactive oxygen species. Kidney International (2010) 77, 85–87. doi:10.1038/ki.2009.432
图中的观点需要商榷，氢气目前不能证明能中和超氧自由基。
Given
previous data, the interpretation that the
benefi cial eff ects of H 2 in a kidney transplant
model are a result of antioxidant
properties of the element is reasonable
and likely. However, this may not be the
sole explanation, and other as-yet undefi
ned mechanisms may be involved. Th e
presence of basal levels of H 2 indicates one
or more endogenous sources, suggesting
that it plays a physiological role. Precedent
for this possibility can be easily found in
other gas-generating systems.
Therefore, given the
increasing number of systems in which H 2
is being shown to mediate beneficial
eff ects, and likely, in the future, deleterious
ones as well, it is probable that involvement
of H 2 in signaling pathways or other
physiological functions will be found.
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发表于 2011-2-6 15:17:26