Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

Park S-J,Ahmad F,Philp A,Baar K,Williams T,Luo H,Ke H,Rehmann H,Taussig R,Brown A L,Kim M K,Beaven M A,Burgin A B,Manganiello V,Chung J H

A role for small RNAs in DNA double-strand break repair

Wei W,Ba Z,Gao M,Wu Y,Ma Y,Amiard S,White CI,Rendtlew Danielsen JM,Yang Y-G,Qi Y

Three-dimensional folding and functional organization principles of the Drosophila genome

Sexton T,Yaffe E,Kenigsberg E,Bantignies F,Leblanc B,Hoichman M,Parrinello H,Tanay A,Cavalli G

A whole-cell computational model predicts phenotype from genotype

Karr JR,Sanghvi JC,Macklin DN,Gutschow MV,Jacobs JM,Bolival BJ,Assad-Garcia N,Glass JI,Covert MW

Personal omics profiling reveals dynamic molecular and medical phenotypes

Chen R,Mias GI,Li-Pook-Than J,Jiang L,Lam HYK,Chen R,Miriami E,Karczewski KJ,Hariharan M,Dewey FE,Cheng Y,Clark MJ,Im H,Habegger L,Balasubramanian S,O'Huallachain M,Dudley JT,Hillenmeyer S,Haraksingh R,Sharon D,Euskirchen G,Lacroute P,Bettinger K,Boyle AP,Kasowski M,Grubert F,Seki S,Garcia M,Whirl-Carrillo M,Gallardo M,Blasco MA,Greenberg PL,Snyder P,Klein TE,Altman RB,Butte AJ,Ashley EA,Gerstein M,Nadeau KC,Tang H,Snyder M

Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks

Lee MJ,Ye AS,Gardino AK,Heijink AM,Sorger PK,MacBeath G,Yaffe MB

Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase

Buganim Y,Faddah DA,Cheng AW,Itskovich E,Markoulaki S,Ganz K,Klemm SL,van Oudenaarden A,Jaenisch R

Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD

Han J,Kesner P,Metna-Laurent M,Duan T,Xu L,Georges F,Koehl M,Abrous DN,Mendizabal-Zubiaga J,Grandes P,Liu Q,Bai G,Wang W,Xiong L,Ren W,Marsicano G,Zhang X

piRNAs initiate an epigenetic memory of nonself RNA in the C. elegans germline

Shirayama M,Seth M,Lee H-C,Gu W,Ishidate T,Conte DJ,Mello CC

Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human

Wu J,Bostrom P,Sparks LM,Ye L,Choi JH,Giang A-H,Khandekar M,Virtanen KA,Nuutila P,Schaart G,Huang K,Tu H,van Marken Lichtenbelt WD,Hoeks J,Enerback S,Schrauwen P,Spiegelman BM

Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict

Samstein RM,Josefowicz SZ,Arvey A,Treuting PM,Rudensky AY

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

Yu F-X,Zhao B,Panupinthu N,Jewell JL,Lian I,Wang LH,Zhao J,Yuan H,Tumaneng K,Li H,Fu X-D,Mills GB,Guan K-L