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Polo and Aurora kinases: lessons derived from chemical biology

阿平添加于 2009-5-19 17:38 | 3430 次阅读 | 0 个评论

作者
Taylor S, Peters J-M
摘要
During the cell division cycle, mitotic entry, spindle assembly, chromosome segregation, and cytokinesis must all be carefully coordinated to ensure that the two daughter cells inherit all the genetic material required for further growth and development. Central to this coordination are several protein kinases including Aurora A, Aurora B, and the Polo-like kinase, Plk1. A number of small-molecule Aurora and Plk1 inhibitors have been developed because these kinases are seen as attractive anticancer drug targets. These inhibitors are now being widely used as chemical biology tools to understand how these kinases ensure faithful genome transmission.
详细资料
- 关键词: Animals; Antineoplastic Agents/chemistry/pharmacology; Cell Cycle Proteins/*antagonists & inhibitors/*metabolism; Chromosome Segregation/drug effects; Enzyme Inhibitors/chemistry/*pharmacology; Humans; Mitosis/*drug effects; Protein-Serine-Threonine Kinases/*antagonists & inhibitors/*metabolism; Proto-Oncogene Proteins/*antagonists & inhibitors/*metabolism
- 文献种类: Journal Article
- 期刊名称: Current Opinion in Cell Biology
- 期刊缩写: Curr Opin Cell Biol
- 期卷页: 2008年第20卷第1期 77-84页
- 地址: Faculty of Life Sciences, University of Manchester, Michael Smith Building, Manchester, UK. stephen.taylor@manchester.ac.uk
- ISBN: 0955-0674
- 备注:PMID:18249108
学科领域生物医药 » 生物学
标签

Polo Aurora 小分子抑制剂
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