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Locomotor activity in a novel environment predicts both responding for a visual stimulus and self-administration of a low dose of methamphetamine in rats

热1 shenww 添加于 2011-1-16 22:53 | 3156 次阅读 | 2 个评论

作者
Gancarz AM, George MAS, Ashrafioun L, Richards JB
摘要
There is evidence that visual stimuli used to signal drug delivery in self-administration procedures have primary reinforcing properties, and that drugs of abuse enhance the reinforcing properties of such stimuli. Here, we explored the relationships between locomotor activity, responding for a visual stimulus, and self-administration of methamphetamine (METH). Rats were classified as high or low responders based on activity levels in a novel locomotor chamber and were subsequently tested for responding to produce a visual stimulus followed by self-administration of a low dose of METH (0.025 mg/kg/infusion) paired with the visual stimulus. High responder rats responded more for the visual stimulus than low responder rats indicating that the visual stimulus was reinforcing and that operant responding for a visual stimulus has commonalities with locomotor activity in a novel environment. Similarly, high responder rats responded more for METH paired with a visual stimulus than low responder rats. Because of the reinforcing properties of the visual stimulus, it was not possible to determine if the rats were responding to produce the visual stimulus, METH or the combination. We speculate that responding to produce sensory reinforcers may be a measure of sensation seeking. These results indicate that visual stimuli have unconditioned reinforcing effects which may have a significant role in acquisition of drug self-administration, a role that is not yet well understood. Research highlights Rats increase responding to produce a response ontingent visual stimulus. Exploratory activity predicts the reinforcing properties of visual stimuli. Visual stimuli may play a role in studies of drug self-administration.
详细资料
- 文献种类: Journal Article
- 期刊名称: Behavioural Processes
- 期刊缩写: Behavioural Processes
- 期卷页: 2011年
- 其他日期: Available online 5 Januar ...
- ISBN: 0376-6357
- 备注:a Research Institute on Addictions, University at Buffalo, SUNY, 1021 Main St., Buffalo, NY 14203, United States b Department of Psychology, University at Buffalo, SUNY, Park Hall, Buffalo, NY 14260, United States
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有点意思的一篇文章。视觉刺激本身具有非条件性强化效应。