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Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction

热1 cnefs 添加于 2011-9-5 07:37 | 2773 次阅读 | 0 个评论

作者
Wen Z, Zheng S, Zhou C, Wang J, Wang T
摘要
The prognosis of patients with myocardial infarction (MI) and resultant chronic heart failure remains extremely poor despite advances in optimal medical therapy and interventional procedures. Animal experiments and clinical trials using adult stem cell therapy following MI have shown a global improvement of myocardial function. Bone marrow-derived mesenchymal stem cells (MSCs) hold promise for cardiac repair following MI, due to their multilineage, self-renewal and proliferation potential. In addition, MSCs can be easily isolated, expanded in culture, and have immunoprivileged properties to the host tissue. Experimental studies and clinical trials have revealed that MSCs not only differentiate into cardiomyocytes and vascular cells, but also secrete amounts of growth factors and cytokines which may mediate endogenous regeneration via activation of resident cardiac stem cells and other stem cells, as well as induce neovascularization, anti-inflammation, anti-apoptosis, anti-remodelling and cardiac contractility in a paracrine manner. It has also been postulated that the anti-arrhythmic and cardiac nerve sprouting potential of MSCs may contribute to their beneficial effects in cardiac repair. Most molecular and cellular mechanisms involved in the MSC-based therapy after MI are still unclear at present. This article reviews the potential repair mechanisms of MSCs in the setting of MI.
详细资料
- 文献种类: Journal Article
- 期刊名称: Journal of Cellular and Molecular Medicine
- 期刊缩写: J Cell Mol Med
- 期卷页: 2011年第15卷第5期 1032-1043页
- 地址: The Sun Yat-sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, China
- ISBN: 1582-1838
- 备注:PMID:21199333
学科领域生物医药 » 临床医学
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干细胞研究 cell
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骨髓间充质干细胞心梗修复机制
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骨髓间充质干细胞修复心梗的机制

MSC可在体外分化为心肌细胞。动物实验和临床试验已经证明MSC可以有效治疗心梗。
MSC治疗心梗的机制主要为：
1.分化分化成为心肌细胞、血管平滑肌细胞和内皮细胞
2.分泌分泌一些因子抗炎、强心、抗凋亡、抗重塑、调节心肌代谢和神经血管作用
3.其他一些神经调节和抗心律失常
其中分泌途径起重要作用
1.心脏再生 VEGF IGF-1 HGF BMP-2 TGF-b SDF-1 FGF-2 Sfrp2
2.神经血管 VEGF IGF-1 HGF TGF-b SDF-1 bFGF PDGF-BB PGF Ang-1 MMP-2 MMP-9
3.抗炎 IL-4 IL-10 PGE-2 HIF-1a TGF-b TSP-1 IL-6
4.强心 VEGF HGF bFGF TB-4 FGF-2 IGF-1 TGF-b
5.抗重塑 MMP-2 MMP-9 TIMP-1 TIMP-2 TIMP-9 IL-10 TB-4 TGF-b HGF TenacinC SDF-1 ADM IGF-1
6.抗凋亡 VEGF IGF-1 HGF bFGF TNF-a SDF-1 TB-4 Sfrp2 EPO FGF-2 ADM BMP-2

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