Neurotoxicant-induced animal models of Parkinson?s disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration
pharmaron 添加于 2011-11-7 11:21
| 1702 次阅读 | 0 个评论
作 者
Uversky VN 摘 要
The etiologic basis of Parkinson’s disease (PD),
the second most common age-related neurodegenerative
disorder, is unknown. Recent epidemiological and experimental
studies indicate that exposure to environmental
agents, including a number of agricultural chemicals, may
contribute to the pathogenesis of this disorder. Animal
models are important tools in experimental medical
science for studying the pathogenesis and therapeutic
intervention strategies of human diseases. Since many
human disorders do not arise spontaneously in animals,
characteristic functional changes have to be mimicked by
neurotoxic agents. Recently, agricultural chemicals, when
administrated systemically, have been shown to reproduce
specific features of PD in rodents, thus opening new routes
for the development of animal models for this disorder. In
addition to a brief historical overview of the toxin-induced
PD models, this study provides a detailed description of
exiting models in which Parkinsonism is initiated via the
exposure of animals to such agricultural chemicals as
rotenone, paraquat, and maneb. Suggested neurotoxicity
mechanisms of these chemicals are considered, and the
major lessons learned from the analysis of pesticideinduced
PD models are discussed.-
详细资料
- 文献种类: Journal Article
- 期刊名称: Cell and Tissue Research
- 期刊缩写: Cell Tissue Res
- 期卷页: 2004年 第318卷 第1期 225-241页
- ISBN: 0302-766X
-
标 签
评论( 人)
学科领域 生物医药 » 药学
浙公网安备 33010202000686号 ( 浙ICP备09035230号-1 )
