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Meta-analysis in clinical trials

karmarks 添加于 2013-3-16 19:10 | 1971 次阅读 | 0 个评论

作者
DerSimonian R, Laird N
摘要
This paper examines eight published reviews each reporting results from several related trials. Each review pools the results from the relevant trials in order to evaluate the efficacy of a certain treatment for a specified medical condition. These reviews lack consistent assessment of homogeneity of treatment effect before pooling. We discuss a random effects approach to combining evidence from a series of experiments comparing two treatments. This approach incorporates the heterogeneity of effects in the analysis of the overall treatment efficacy. The model can be extended to include relevant covariates which would reduce the heterogeneity and allow for more specific therapeutic recommendations. We suggest a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.
详细资料
- 文献种类: Journal Article
- 期刊名称: Controlled Clinical Trials
- 期刊缩写: Controlled Clinical Trials
- 期卷页: 1986年第7卷第3期 177-188页
- ISBN: 0197-2456
学科领域生物医药 » 预防卫生学
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