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TRPM channels in the vasculature

牛老师添加于 2015-5-12 19:27 | 1686 次阅读 | 0 个评论

作者
Zholos A, Johnson C, Burdyga T, Melanaphy D
摘要
Recent studies show that mammalian melastatin TRPM nonselective cation channels (TRPM1-8), members of the largest and most diverse TRP subfamily, are widely expressed in the endothelium and vascular smooth muscles. When activated, these channels similarly to other TRPs permit the entry of sodium, calcium and magnesium, thus causing membrane depolarisation. Although membrane depolarisation reduces the driving force for calcium entry via TRPMs as well as other pathways for calcium entry, in smooth muscle myocytes expressing voltage-gated Ca(2+) channels the predominant functional effect is an increase in intracellular Ca(2+) concentration and myocyte contraction. This review focuses on several best documented aspects of vascular functions of TRPMs, including the role of TRPM2 in oxidant stress, regulation of endothelial permeability and cell death, the connection between TRPM4 and myogenic response, significance of TRPM7 for magnesium homeostasis, vessel injury and hypertension, and emerging evidence that the cold and menthol receptor TRPM8 is involved in the regulation of vascular tone.
详细资料
- 关键词: Blood Vessels/*metabolism; Calcium Channels/metabolism; Humans; Ion Channel Gating; Oxidative Stress; TRPM Cation Channels/*metabolism
- 文献种类: Journal Article
- 期刊名称: Advances in Experimental Medicine and Biology
- 期刊缩写: Adv Exp Med Biol
- 期卷页: 2011年第704卷 707-729页
- 地址: Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Sciences, Royal Victoria Hospital, Queen\'s University of Belfast, Belfast BT12 6BA, UK. a.zholos@qub.ac.uk
- ISBN: 0065-2598
学科领域生物医药 » 基础医学
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