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An efficient organocatalytic method for constructing biaryls through aromatic C–H activation

mjl123 添加于 2015-5-28 16:27 | 1362 次阅读 | 0 个评论

作者
Sun C-L, Li H, Yu D-G, Yu M, Zhou X, Lu X-Y, Huang K, Zheng S-F, Li B-J, Shi Z-J
摘要
The direct functionalization of C–H bonds has drawn the attention of chemists for almost a century. C–H activation has mainly been achieved through four metal-mediated pathways: oxidative addition, electrophilic substitution, σ-bond metathesis and metal-associated carbene/nitrene/oxo insertion. However, the identification of methods that do not require transition-metal catalysts is important because methods involving such catalysts are often expensive. Another advantage would be that the requirement to remove metallic impurities from products could be avoided, an important issue in the synthesis of pharmaceutical compounds. Here, we describe the identification of a cross-coupling between aryl iodides/bromides and the C–H bonds of arenes that is mediated solely by the presence of 1,10-phenanthroline as catalyst in the presence of KOt-Bu as a base. This apparently transition-metal-free process provides a new strategy with which to achieve direct C–H functionalization.
详细资料
- 文献种类: Journal Article
- 期刊名称: Nature Chemistry
- 期刊缩写: Nature Chem
- 期卷页: 2010年
- ISBN: 1755-4330
学科领域自然科学 » 化学
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附件
An efficient organocatalytic method for constructing biaryls through aromatic C–