新科学想法 › 学术文库 › 学术文献 › 浏览文献

Mesenchymal stem cells in health and disease

yonghit 添加于 2015-11-23 10:43 | 1384 次阅读 | 0 个评论

作者
Uccelli A, Moretta L, Pistoia V
摘要
Mesenchymal stem cells (MSCs) are a heterogeneous subset of stromal stem cells that can be isolated from many adult tissues. They can differentiate into cells of the mesodermal lineage, such as adipocytes, osteocytes and chondrocytes, as well as cells of other embryonic lineages. MSCs can interact with cells of both the innate and adaptive immune systems, leading to the modulation of several effector functions. After in vivo administration, MSCs induce peripheral tolerance and migrate to injured tissues, where they can inhibit the release of pro-inflammatory cytokines and promote the survival of damaged cells. This Review discusses the targets and mechanisms of MSC-mediated immunomodulation and the possible translation of MSCs to new therapeutic approaches.
详细资料
- 关键词: Adaptation, Biological/immunology; Animals; Cell Differentiation/immunology; *Disease; *Health; Humans; Immunity, Innate/immunology; Mesenchymal Stromal Cells/*cytology/*immunology
- 文献种类: Journal Article
- 期刊名称: Nature Reviews. Immunology
- 期刊缩写: Nat Rev Immunol
- 期卷页: 2008年第8卷第9期 726-736页
- 地址: Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy. auccelli@neurologia.unige.it
- ISBN: 1474-1733
学科领域自然科学 » 化学
相关链接 DOI URL