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有读书笔记有附件Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch

阿平 添加于 2015-12-19 06:04 | 3823 次阅读 | 0 个评论

  •  作 者

    Qian J, Beullens M, Huang J, De Munter S, Lesage B, Bollen M

  •  摘 要

    RepoMan is a scaffold for signalling by mitotic phosphatases at the chromosomes. During (pro)metaphase, RepoMan-associated protein phosphatases PP1 and PP2A-B56 regulate the chromosome targeting of Aurora-B kinase and RepoMan, respectively. Here we show that this task division is critically dependent on the phosphorylation of RepoMan by protein kinase Cyclin-dependent kinase 1 (Cdk1), which reduces the binding of PP1 but facilitates the recruitment of PP2A-B56. The inactivation of Cdk1 in early anaphase reverses this phosphatase switch, resulting in the accumulation of PP1-RepoMan to a level that is sufficient to catalyse its own chromosome targeting in a PP2A-independent and irreversible manner. Bulk-targeted PP1-RepoMan also inactivates Aurora B and initiates nuclear-envelope reassembly through dephosphorylation-mediated recruitment of Importin β. Bypassing the Cdk1 regulation of PP1-RepoMan causes the premature dephosphorylation of its mitotic-exit substrates in prometaphase. Hence, the regulation of RepoMan-associated phosphatases by Cdk1 is essential for the timely dephosphorylation of their mitotic substrates.

  •  详细资料

    • 文献种类: Journal Article
    • 期刊名称: Nature Communications
    • 期刊缩写: Nat Comms
    • 期卷页: 2015年  第6卷 10215页
    • ISBN: 2041-1723

  • 学科领域 生物医药 » 生物学

  •  所属群组

    细胞周期  

  • 相关链接 DOI URL 

  •  附 件

    PDF附件文章全文  PDF附件附件 

  •  阿平 的文献笔记  订阅

    有丝分裂的那点事之烈女传
    拙作终于发表，我的研究讲述了一个有丝分裂期间曲折的爱情故事。话说RepoMan和PP1从小青梅竹马，形影不离。无奈嫁娶之时独断专行的族长Cdk1以PP1与自己命中相克为由，强行将其与RepoMan拆散。然后找来一个听话的PP2A与RepoMan强逼成婚。但万事总有天数，族长Cdk1油尽灯枯之时，PP1通过自身努力以及某个神秘人物的出手相救，终于排除万难与RepoMan再续前缘。而此时PP2A选择了成全，悄然离开。从此RepoMan和PP1通过努力工作，过上了幸福的生活。
    神秘人物到底是谁？他又是如何解救PP1的？请听下回分解！
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