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Significance of signet-ring cells in patients with colorectal cancer

longfeilujun 添加于 2018-7-12 22:47 | 1185 次阅读 | 0 个评论

作者
Pande R, Sunga A, Levea C, Wilding GE, Bshara W, Reid M, Fakih MG
摘要
PURPOSE: We performed a retrospective study to determine the pattern of metastases and overall outcome of patients with tumors exhibiting a component of signet-ring cells comprising < 50 percent of the tumor mass. METHODS: Medical records of 753 patients with primary colorectal cancer were retrospectively studied. Patients who had tumors with < 50 percent signet-ring cells were classified as having a component of signet-ring cells. The outcome of patients with a component of signet-ring cells was compared to all patients with mucinous adenocarcinoma (defined as adenocarcinomas with > or = 50 percent mucin) to all patients with adenocarcinomas with a component of mucin (defined as adenocarcinomas with < 50 percent mucin) and to 100 randomly selected patients with adenocarcinomas lacking mucin or signet-ring cells. RESULTS: Five percent of patients had a component of signet-ring cells, 3 percent had mucinous adenocarcinoma, 9 percent had a component of mucinous adenocarcinoma, and 83 percent had adenocarcinoma lacking mucinous or signet components. Patients with a component of signet-ring cells and mucinous adenocarcinomas metastasized predominantly to the peritoneum/ovaries (75 and 56 percent of metastatic cases, respectively) and rarely to liver/lungs. The pattern of metastases of patients with adenocarcinoma without mucinous or signet components predominantly involved the liver/lungs and rarely the peritoneum/ovaries (12.5 percent). The pattern of metastases for patients with a component of mucinous adenocarcinoma was intermediate between mucinous adenocarcinoma and adenocarcinoma without mucin or signet-ring component. No differences in survival in Stage IV patients were seen among the four subgroups. CONCLUSIONS: Patients with a component of signet-ring cells cancers, similar to mucinous adenocarcinoma, have a predisposition to metastasize to the peritoneum/ovaries.
详细资料
- 关键词: Adenocarcinoma, Mucinous/epidemiology/*pathology; Carcinoma, Signet Ring Cell/epidemiology/*pathology; Colorectal Neoplasms/epidemiology/*pathology; Female; Humans; Incidence; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Retrospective Studies; Survival Analysis
- 文献种类: Journal Article
- 期刊名称: Diseases of the Colon and Rectum
- 期刊缩写: Dis Colon Rectum
- 期卷页: 2008年第51卷第1期 50-55页
- 地址: University at Buffalo/Roswell Park Cancer Institute, Elm and Carlton, Buffalo, NY 14263, USA
- ISBN: 0012-3706
学科领域生物医药 » 临床医学
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