新科学想法 › 学术文库 › 学术文献 › 浏览文献

Primary signet-ring cell carcinoma of the colon and rectum

longfeilujun 添加于 2018-7-12 22:50 | 2239 次阅读 | 0 个评论

作者
Messerini L, Palomba A, Zampi G
摘要
PURPOSE: Colorectal signet-ring cell carcinoma (SRCC) is uncommon; discordant data have been previously reported about clinicopathologic features. Thirty-four cases of primary colorectal SRCC were retrospectively reviewed to clarify controversies. METHODS: Primary colorectal SRCC was diagnosed when the following criteria were satisfied: 1) the tumor was primary; 2) histologic material was adequate; 3) signet-ring cell represented more than 50 percent of the cancer. RESULTS: We identified 34 cases (1.1 percent) of 2,995 consecutive large bowel cancers collected at the Institute of Anatomic Pathology of Florence between 1985 and 1993. Patients ranged in age from 31 to 89 (mean, 63.5; median, 65) years; 19 were male, and 15 were female (male:female = 1.3:1). Fifteen tumors were located in the proximal colon, 11 in the rectum, and 8 in the distal colon. The gross shape was infiltrative in 24 cases and exophytic in 10; only 6 cases (17.6 percent) showed features of linitis plastica. Most cancers (61.8 percent) were Stage C, 29.4 percent were Stage B, and distant metastases were present in only three cases (8.8 percent). No Stage A case was found. Prognosis was extremely poor, and overall five-year survival rate was 9.1 percent. Survival was influenced significantly by tumor stage (P < 0.01). CONCLUSIONS: Comparison of our data with the literature showed many differences that could be related to different applied diagnostic criteria. We underlined the importance of histology as reproducible criterion for diagnosis of primary colorectal SRCC.
详细资料
- 关键词: Adult; Aged; Aged, 80 and over; Carcinoma, Signet Ring Cell/mortality/*pathology/secondary; Colorectal Neoplasms/mortality/*pathology; Female; Humans; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Retrospective Studies; Survival Rate
- 文献种类: Journal Article
- 期刊名称: Diseases of the Colon and Rectum
- 期刊缩写: Dis Colon Rectum
- 期卷页: 1995年第38卷第11期 1189-1192页
- 地址: Institute of Anatomic Pathology, University of Florence, Italy
- ISBN: 0012-3706
学科领域生物医药 » 临床医学
相关链接 URL