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Survival in signet ring cell carcinoma varies based on primary tumor location: a Surveillance, Epidemiology, and End Results database analysis

longfeilujun 添加于 2018-7-12 22:53 | 1124 次阅读 | 0 个评论

作者
Wu S-G, Chen X-T, Zhang W-W, Sun J-Y, Li F-Y, He Z-Y, Pei X-Q, Lin Q
摘要
BACKGROUND: The aim of this study was to investigate the survival of patients with signet ring cell carcinoma (SRCC) based on primary tumor location. METHODS: Patient data were obtained from the Surveillance, Epidemiology, and End Results database (1988-2012) with >/=200 cases per tumor location. Cox regression analysis was used to investigate prognostic factors of cause-specific survival (CSS). RESULTS: We identified 24,171 patients. Of the patients, 63.4% had gastric SRCC, followed by colon (18.2%), esophageal (5.0%), rectal (3.5%), lung (3.1%), pancreatic (1.8%), breast (1.5%), bladder (1.3%), small intestine (1.1%), and gallbladder SRCC (1.0%). The 5-year CSS was 22.1%, 69.0%, 33.2%, 28.1%, 24.8%, 16.1%, 13.6%, 12.6%, 11.0%, 6.4% in patients with gastric, breast, colon, rectum, bladder, small intestine, esophageal, gallbladder, lung, and pancreatic SRCC, respectively (P < 0.001). Multivariate analyses showed that the primary tumor location was an independent prognostic factor of survival. Patients with lung, small intestine, and bladder SRCC had a comparable CSS to gastric SRCC, while breast and colorectal SRCC had better survival than gastric SRCC. Esophageal, gallbladder, and pancreatic SRCC were significantly associated with poor CSS compared with gastric SRCC. CONCLUSION: Our study suggests a major difference in survival of SRCC based on the primary tumor locations.
详细资料
- 关键词: Seer; Signet ring cell carcinoma; surgery; survival; tumor sites
- 文献种类: Journal Article
- 期刊名称: Expert Review of Gastroenterology & Hepatology
- 期刊缩写: Expert Rev Gastroenterol Hepatol
- 期卷页: 2018年第12卷第2期 209-214页
- 地址: a Department of Radiation Oncology , Xiamen Cancer Hospital, The First Affiliated Hospital of Xiamen University , Xiamen , People\'s Republic of China
- ISBN: 1747-4124
学科领域生物医药 » 临床医学
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