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Systems biology: the reincarnation of systems theory applied in biology?

热1 yunwang 添加于 2010-1-9 20:55 | 2074 次阅读 | 0 个评论

作者
Wolkenhauer O
摘要
With the availability of quantitative data on the transcriptome and proteome level, there is an increasing interest in formal mathematical models of gene expression and regulation. International conferences, research institutes and research groups concerned with systems biology have appeared in recent years and systems theory, the study of organisation and behaviour per se, is indeed a natural conceptual framework for such a task. This is, however, not the first time that systems theory has been applied in modelling cellular processes. Notably in the 1960s systems theory and biology enjoyed considerable interest among eminent scientists, mathematicians and engineers. Why did these early attempts vanish from research agendas? Here we shall review the domain of systems theory, its application to biology and the lessons that can be learned from the work of Robert Rosen. Rosen emerged from the early developments in the 1960s as a main critic but also developed a new alternative perspective to living systems, a concept that deserves a fresh look in the post-genome era of bioinformatics.
详细资料
- 关键词: Causality; *Computational Biology; Gene Expression Regulation; Metabolism; *Models, Genetic; *Systems Theory
- 文献种类: Journal Article
- 期刊名称: Briefings in Bioinformatics
- 期刊缩写: Brief Bioinform
- 期卷页: 2001年第2卷第3期 258-270页
- 地址: Department of Biomolecular Sciences, Control Systems Centre, UMIST, Manchester, UK. o.wolkenhauer@umist.ac.uk
- ISBN: 1467-5463
- 备注:PMID:11589586
学科领域生物医药 » 中医中药学
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Systems biology: the reincarnation of systems theory applied in biology?