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Protein dynamics in drug combinations: a linear superposition of individual-drug responses

xbinbzy 添加于 2010-4-26 22:19 | 1985 次阅读 | 0 个评论

作者
Geva-Zatorsky N, Dekel E, Cohen AA, Danon T, Cohen L, Alon U
摘要
Drugs and drug combinations have complex biological effects on cells and organisms. Little is known about how drugs affect protein dynamics that determine these effects. Here, we use a dynamic proteomics approach to accurately follow 15 protein levels in human cells in response to 13 different drugs. We find that protein dynamics in response to combinations of drugs are described accurately by a linear superposition (weighted sum) of their response to individual drugs. The weights in this superposition describe the relative impact of each drug on each protein. Using these weights, we show that one can predict the dynamics in a three-drug or four-drug combination on the basis of the dynamics in drug pairs. Our approach might eliminate the need to increase the number of experiments exponentially with the number of drugs and suggests that it might be possible to rationally control protein dynamics with specific drug combinations.
详细资料
- 关键词: Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Combinations; *Drug Interactions; Gene Expression/*drug effects; Humans; Proteins/*chemistry
- 文献种类: Journal Article
- 期刊名称: Cell
- 期刊缩写: Cell
- 期卷页: 2010年第140卷第5期 643-651页
- 地址: Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot 76100, Israel
- ISBN: 0092-8674
- 备注:PMID:20211134
学科领域生物医药 » 中医中药学
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