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ATP-dependent chromatin remodeling factors: nucleosome shufflers with many missions

热1 鹿特丹添加于 2009-7-15 05:35 | 2680 次阅读 | 0 个评论

作者
Varga-Weisz P
摘要
This review addresses recent developments in the field of ATP-dependent chromatin remodeling factors. These factors use the energy of ATP hydrolysis to introduce superhelical torsion into DNA, which suggests a common mechanistic basis of action. Chromatin remodeling factors function both in transcriptional activation and repression, but they may have roles outside of transcriptional regulation such as DNA repair. A study of the nucleosome dependent ATPase ISWI in yeast illustrates the involvement of ATP-dependent chromatin remodeling in transcriptional repression by setting up inaccessible chromatin structures at promoters. However, factors such as ISWI are also involved in the restructuring of large chromatin domains and even whole chromosomes. Transcriptional regulation by ATP-dependent chromatin remodeling factors occurs in concert with histone modifying enzymes such as histone acetyltransferases and histone deacetylases: In yeast, SWI/SNF targeting is a requirement for histone acetyltransferases activity at promoters that are active at late stages of mitosis, when the chromatin is still condensed. This demonstrates that ATP-dependent remodeling factors facilitate covalent histone modifications. However, they are also regulated by histone modifications and in some circumstances they function in parallel with histone modifications towards the same goal.
详细资料
- 关键词: Adenosine Triphosphatases/metabolism; Adenosine Triphosphate/*metabolism; Animals; Chromatin/*genetics/metabolism; Gene Expression Regulation; Humans; Nucleosomes/genetics/metabolism; Transcription Factors/metabolism
- 文献种类: Journal Article
- 期刊名称: Oncogene
- 期刊缩写: Oncogene
- 期卷页: 2001年第20卷第24期 3076-3085页
- 地址: Marie Curie Research Institute, The Chart, Oxted, Surrey, RH8 OTL, UK
- ISBN: 0950-9232
- 备注:PMID:11420723
学科领域农业科学 » 农学
标签

ATP 染色体 chromatin remodel
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附件
ATP-dependent chromatin remodeling factors: nucleosome shufflers with many missions

鹿特丹的文献笔记订阅

ATP-dependent chromatin remodeling factors alter the
positions of nucleosomes along DNA, rendering DNA
either accessible or inaccessible
ATP-dependent chromatin remodeling activities generate
superhelical torsion, which translates to nucleosome
remodeling
ATP-dependent chromatin remodeling are recruited to
promoters and cooperate with histone modifying enzymes
ATP-dependent chromatin remodeling factors may
translate the ‘nucleosomal code’?
ATP-dependent chromatin remodeling may change the
chromatin structure of whole domains
ATP-dependent chromatin remodeling may have
functions outside of transcriptional regulation