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有读书笔记Fabrication of microscale medical devices by two-photon polymerization with multiple foci via a spatial light modulator

唐唐 添加于 2011-11-4 05:56 | 1545 次阅读 | 0 个评论
  •  作 者

    Gittard SD, Nguyen A, Obata K, Koroleva A, Narayan RJ, Chichkov BN
  •  摘 要

    Two-photon polymerization is an appealing technique for producing microscale devices due to its flexibility in producing structures with a wide range of geometries as well as its compatibility with materials suitable for biomedical applications. The greatest limiting factor in widespread use of two-photon polymerization is the slow fabrication times associated with line-by-line, high-resolution structuring. In this study, a recently developed technology was used to produce microstructures by two-photon polymerization with multiple foci, which significantly reduces the production time. Computer generated hologram pattern technology was used to generate multiple laser beams in controlled positions from a single laser. These multiple beams were then used to simultaneously produce multiple microstructures by two-photon polymerization. Arrays of micro-Venus structures, tissue engineering scaffolds, and microneedle arrays were produced by multifocus two-photon polymerization. To our knowledge, this work is the first demonstration of multifocus two-photon polymerization technology for production of a functional medical device. Multibeam fabrication has the potential to greatly improve the efficiency of two-photon polymerization production of microscale devices such as tissue engineering scaffolds and microneedle arrays.
  •  详细资料

    • 文献种类: Journal Article
    • 期刊名称: Biomedical Optics Express
    • 期刊缩写: Biomed. Opt. Express
    • 期卷页: 2011  2 11 3167
    • ISBN: 2156-7085
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    科学家发明组织支架构建新技术
    近日,来自德国和美国的科学家通过改造双光子聚合技术(2PP),使得研究人员可以更快更有效地建立及其精致的微结构,如组织支架等。相关研究近日发表在《生物医学光学快讯》上。
     
    2PP技术可以用来制造很多调控细胞等微结构的小工具。用传统2PP技术,制造100纳米分辨率的1平方毫米单层组织需要2小时47分;而用改进后的2PP技术则仅仅需要10分钟。
     
    本研究为局限于实验室的2PP技术走向临床应用铺平了道路。研究者的下一个目标是利用该系统建立一个更大的3D组织结构。(科学网 任春晓/编译)
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