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Fabrication of microscale medical devices by two-photon polymerization with multiple foci via a spatial light modulator

唐唐添加于 2011-11-4 05:56 | 1666 次阅读 | 0 个评论

作者
Gittard SD, Nguyen A, Obata K, Koroleva A, Narayan RJ, Chichkov BN
摘要
Two-photon polymerization is an appealing technique for producing microscale devices due to its flexibility in producing structures with a wide range of geometries as well as its compatibility with materials suitable for biomedical applications. The greatest limiting factor in widespread use of two-photon polymerization is the slow fabrication times associated with line-by-line, high-resolution structuring. In this study, a recently developed technology was used to produce microstructures by two-photon polymerization with multiple foci, which significantly reduces the production time. Computer generated hologram pattern technology was used to generate multiple laser beams in controlled positions from a single laser. These multiple beams were then used to simultaneously produce multiple microstructures by two-photon polymerization. Arrays of micro-Venus structures, tissue engineering scaffolds, and microneedle arrays were produced by multifocus two-photon polymerization. To our knowledge, this work is the first demonstration of multifocus two-photon polymerization technology for production of a functional medical device. Multibeam fabrication has the potential to greatly improve the efficiency of two-photon polymerization production of microscale devices such as tissue engineering scaffolds and microneedle arrays.
详细资料
- 文献种类: Journal Article
- 期刊名称: Biomedical Optics Express
- 期刊缩写: Biomed. Opt. Express
- 期卷页: 2011年第2卷第11期 3167页
- ISBN: 2156-7085
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