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The use of erythropoietin in patients undergoing radical prostatectomy: effects on hematocrit, transfusion rates and quality of life

oyc1014 添加于 2016-2-23 21:19 | 981 次阅读 | 0 个评论

作者
Gaston KE, Kouba E, Moore DT, Pruthi RS
摘要
OBJECTIVE: It was the aim of this study to prospectively study the effects on hematocrit levels, transfusion rates and quality of life (QOL) indices in men preoperatively supplemented with recombinant erythropoietin (rEPO) undergoing radical prostatectomy for clinically localized prostate cancer. METHODS: Thirty men undergoing radical prostatectomy were randomized either to receive rEPO (n=25) or to serve as controls (n=25). Outcome measurements obtained preoperatively, as well as 10 days and 6 weeks postoperatively included serum hematocrit levels, transfusion rates and QOL indices (using SF-12 validated questionnaires). RESULTS: The rEPO group had a significant increase in preoperative hematocrit (median increase=4 points; p=0.002). Although there were no significant differences in hematocrit at 10 days, the rEPO had a significantly higher hematocrit value at 6 weeks (p=0.0086). No differences were observed in transfusions rates between groups (4% in each group). SF-12 mental and SF-12 physical scores were not different between the two groups at any time point. CONCLUSION: Preoperative administration of rEPO significantly increases preoperative and postoperative hematocrit levels. However, no differences were observed with regard to transfusion rates or postoperative QOL indices despite these higher hematocrit values.
详细资料
- 关键词: Adult; Aged; Blood Transfusion/*statistics & numerical data; Erythropoietin/*therapeutic use; Follow-Up Studies; Hematocrit; Humans; Male; Middle Aged; *Preoperative Care; Prospective Studies; Prostatectomy/*methods; Prostatic Neoplasms/blood/*drug therapy/surgery; *Quality of Life; Recombinant Proteins; Treatment Outcome
- 文献种类: Randomized Controlled Trial
- 期刊名称: Urologia Internationalis
- 期刊缩写: Urol Int
- 期卷页: 2006年第77卷第3期 211-215页
- 地址: Department of Surgery (Urology), The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7235, USA
- ISBN: 0042-1138
学科领域工程技术 » 材料科学
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