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有读书笔记有附件Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon

火箭 添加于 2010-5-4 16:37 | 2137 次阅读 | 0 个评论

  •  作 者

    Cervantes-Barragan L, Zust R, Weber F, Spiegel M, Lang KS, Akira S, Thiel V, Ludewig B

  •  摘 要

    This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-α production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections. (Blood. 2007;109:1131-1137)

  •  详细资料

    • 文献种类: Journal Article
    • 期刊名称: Blood
    • 期刊缩写: Blood
    • 期卷页: 2006年  第109卷 第3期 1131-1137页
    • ISBN: 0006-4971

  • 学科领域 生物医药 » 药学

  •  标 签

    pDC培养 

  • 相关链接 DOI URL 

  •  附 件

    PDF附件Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon 

  •  火箭 的文献笔记  订阅

    Murine bone marrow–derived pDCs’generation

    6 to 7 days of culture with Flt3-L (R&D systems,  Oxford,  United  Kingdom)  at  20  ng/mL. 

    Bone marrow–derived pDCs were purified using the mouse pDC isolation kit (Miltenyi Biotec, Bergisch Gladbach, Germany) adapted for the isolation of in vitro–derived pDCs by adding CD11b-biotin to the negative selection cocktail.

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